N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine

Base Information Edit

Chemical Name:N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine
CAS No.:111669-24-0
Molecular Formula:C11H18 N4
Molecular Weight:206.291
Hs Code.:
DSSTox Substance ID:DTXSID80436005
Nikkaji Number:J964.781C
Wikidata:Q82251173
Mol file:111669-24-0.mol

Synonyms:111669-24-0;N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine;N-ethyl-2-piperazin-1-ylpyridin-3-amine;3-(Ethylamino)-2-(1-piperazinyl)pyridine;1-(3-ethylamino-2-pyridinyl)piperazine;1-[3-ethylamino-2-pyridinyl]piperazine;Jacamine;SCHEMBL3334093;DTXSID80436005;ACCRDWKRCKTUDR-UHFFFAOYSA-N;4-[3-(ethylamino)-2-pyridinyl]piperazine

Suppliers and Price of N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(ETHYLAMINO)-2-(1-PIPERAZINYL)PYRIDINE 95.00%
5MG
$ 498.26

Total 4 raw suppliers

Chemical Property of N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.579
Boiling Point:387.7°Cat760mmHg
Flash Point:188.3°C
PSA：40.19000
Density:1.103g/cm³
LogP:1.38980
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:206.153146591
Heavy Atom Count:15
Complexity:179

Purity/Quality:

98%min ^*data from raw suppliers

3-(ETHYLAMINO)-2-(1-PIPERAZINYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNC1=C(N=CC=C1)N2CCNCC2

Technology Process of N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine

There total 8 articles about N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 111669-24-0
4-[3-(Ethylamino)-2-pyridinyl]-piperazine

Guidance literature:

Reference yield:

: 3-ethylamino-2-[(4-t-butylcarbonyl)-1-piperazinyl]pyridine

: 111669-24-0
4-[3-(Ethylamino)-2-pyridinyl]-piperazine

Guidance literature:: With hydrogenchloride; potassium hydroxide; In water; ethyl acetate;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 111669-24-0
4-[3-(Ethylamino)-2-pyridinyl]-piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetonitrile / 3 h / Heating

2: H₂, 1.2 N aq. HCl / 10percent Pd/C / ethanol / 16 h / 2378.9 Torr

3: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

4: sodium cyanoborohydride / acetonitrile / 48 h / Ambient temperature

5: 3.0 N aq. HCl / ethyl acetate / 16 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm00166a010