2-(Piperazin-1-yl)pyridin-3-amine

Base Information

Chemical Name:2-(Piperazin-1-yl)pyridin-3-amine
CAS No.:87394-62-5
Molecular Formula:C9H14N4
Molecular Weight:178.23400
Hs Code.:2933990090
DSSTox Substance ID:DTXSID20439196
Wikidata:Q82255103
ChEMBL ID:CHEMBL45665
Mol file:87394-62-5.mol

Synonyms:2-(Piperazin-1-yl)pyridin-3-amine;87394-62-5;2-piperazin-1-ylpyridin-3-amine;2-Piperazin-1-yl-pyridin-3-ylamine;CHEMBL45665;3-Pyridinamine,2-(1-piperazinyl)-(9CI);SCHEMBL8415184;DTXSID20439196;KZZRPCPYROZNOE-UHFFFAOYSA-N;1-(3-amino-2-pyridyl)piperazine;3-amino-2-(1-piperazinyl)pyridine;3-Pyridinamine,2-(1-piperazinyl)-;BDBM50027017;GS0770;MFCD09701435;AKOS005208321;AS-60775;FT-0687907;EN300-245969;J-506534;F2113-0207

Suppliers and Price of 2-(Piperazin-1-yl)pyridin-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Frontier Specialty Chemicals
2-(Piperazin-1-yl)pyridin-3-amine 97%
1g
$ 257.00

Crysdot
2-(Piperazin-1-yl)pyridin-3-amine 97%
5g
$ 582.00

Chemenu
2-(Piperazin-1-yl)pyridin-3-amine 95%+
1g
$ 545.00

American Custom Chemicals Corporation
2-(PIPERAZIN-1-YL)PYRIDIN-3-AMINE 95.00%
5MG
$ 505.93

Total 9 raw suppliers

Chemical Property of 2-(Piperazin-1-yl)pyridin-3-amine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:393.998oC at 760 mmHg
PKA:9.35±0.29(Predicted)
Flash Point:192.083oC
PSA：54.18000
Density:1.163g/cm3
LogP:1.04840
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:178.121846464
Heavy Atom Count:13
Complexity:156

Purity/Quality:

97% ^*data from raw suppliers

2-(Piperazin-1-yl)pyridin-3-amine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=C(C=CC=N2)N

Technology Process of 2-(Piperazin-1-yl)pyridin-3-amine

There total 2 articles about 2-(Piperazin-1-yl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 87394-48-7
1-(3-nitro-2-pyridinyl)piperazine

: 87394-62-5
1-(3-amino-pyridin-2-yl)-piperazine

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 25 ℃; for 12h; under 2068.65 Torr;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 87394-62-5
1-(3-amino-pyridin-2-yl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / acetonitrile / 5 h / Heating

2: H₂ / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1021/jm00366a007

Reference yield:

: 87394-62-5
1-(3-amino-pyridin-2-yl)-piperazine

: 111669-26-2
4-(3-ethylaminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: sodium cyanoborohydride / acetonitrile / 48 h / Ambient temperature

With sodium cyanoborohydride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm00166a010