Technology Process of 3-(4-aminomethylbenzyl)-7-(2-fluryl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
There total 5 articles about 3-(4-aminomethylbenzyl)-7-(2-fluryl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; nickel; ammonium hydroxide / ethanol / 16 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C
4.1: sodium hydride / tetrahydrofuran / 0 °C
4.2: 16 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C
With
hydrogenchloride; carbon tetrabromide; hydrogen; nickel; sodium hydride; ammonium hydroxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800961g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C
2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / 0 °C
3.2: 16 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C
With
hydrogenchloride; carbon tetrabromide; sodium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm800961g
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol;
at 20 ℃;
for 16h;
DOI:10.1021/jm800961g
