TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE
• CAS No.: 187283-17-6
• Molecular Formula: C13H18BrNO2
• Molecular Weight: 300.195
• Hs Code.: 2924299090
• Mol file: 187283-17-6.mol

Synonyms:t-Butyl N-[4-(bromomethyl)benzyl]carbamate;4-(Boc-aminomethyl)benzylbromide;tert-butyl N-[4-(bromomethyl)benzyl]carbamate;BrCH2C6H4CH2NHBoc;tert-Butyl 4-(bromomethyl)benzylcarbamate;N-BOC-4-(BROMOMETHYL)BENZYLAMINE;(4-bromomethylbenzyl)carbamic acid tert-butyl ester;

Chemical Property of TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 392.323oC at 760 mmHg
• Flash Point: 191.071oC
• PSA: 38.33000
• Density: 1.305g/cm3
• LogP: 3.99710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(Bromomethyl)benzylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE

There total 10 articles about TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (4-(bromomethyl)phenyl)methanamine hydrobromic salt → (4-bromomethylbenzyl)carbamic acid tert-butyl ester (187283-17-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2007.02.042

Reference yield: 95.0%

tert-butyl 4-hydroxymethylbenzylcarbamate (123986-64-1) → (4-bromomethylbenzyl)carbamic acid tert-butyl ester (187283-17-6)

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

4-Cyanobenzyl alcohol (874-89-5) → (4-bromomethylbenzyl)carbamic acid tert-butyl ester (187283-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran

2: 0.15 g / aq. HBr / H₂O / 3.5 h / Heating

3: 99 percent / NaHCO₃ / dioxane; H₂O / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen bromide; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1016/j.bmc.2007.02.042

upstream raw materials:

di-tert-butyl dicarbonate

4-Cyanobenzyl alcohol

4-hydroxymethyl-benzylamine

4-cyanobenzyl bromide

Downstream raw materials:

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-[4-(tert-butyloxycarbonylaminomethyl)benzylamino]propionic acid methyl ester