(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

Base Information

Chemical Name:(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one
CAS No.:323185-57-5
Molecular Formula:C₁₉H₁₅NO
Molecular Weight:273.334
Hs Code.:

Synonyms:(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

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Chemical Property of (+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

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Technology Process of (+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

There total 8 articles about (+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 323185-56-4
5-phenyl-4H-pyrrolo[1,2-a][1]benzazepin-4-one

: 323185-57-5
(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h; under 760 Torr;
DOI:10.1016/S0040-4020(00)00900-5

Reference yield:

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 323185-57-5
(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 160 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

2.2: 89 percent / 1 h / 20 °C

3.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: 89 percent / PCl₅ / 1,2-dichloro-ethane / 2 h / 20 °C

5.1: 88 percent / H₂ / Pd(C) / ethyl acetate / 2 h / 20 °C / 760 Torr

With lithium hydroxide; phosphorus pentachloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane; 2.2: Wadsworth-Emmons olefination;
DOI:10.1016/S0040-4020(00)00900-5

Reference yield:

: 10333-67-2
methyl 2-(1H-pyrrol-1-yl)benzoate

: 323185-57-5
(+/-)-5,6-dihydro-5-phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / LAH / diethyl ether / 0.25 h

2.1: 95 percent / MnO₂ / benzene / 16 h / Heating

3.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

3.2: 89 percent / 1 h / 20 °C

4.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h / 20 °C

5.1: 89 percent / PCl₅ / 1,2-dichloro-ethane / 2 h / 20 °C

6.1: 88 percent / H₂ / Pd(C) / ethyl acetate / 2 h / 20 °C / 760 Torr

With manganese(IV) oxide; lithium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; benzene; 3.2: Wadsworth-Emmons olefination;
DOI:10.1016/S0040-4020(00)00900-5