(1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide

Base Information

• Chemical Name: (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide
• CAS No.: 130753-27-4
• Molecular Formula: C₁₄H₂₂N₂O₂
• Molecular Weight: 250.341

Synonyms:(1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide

Chemical Property of (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide

Chemical Property:

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Technology Process of (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide

There total 2 articles about (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) + 2-chloro-N,N-dimethylacetamide (2675-89-0) → (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide (130753-27-4)

Guidance literature:

With triethylamine; In benzene; for 8h; Heating;

DOI:10.1021/jo00032a013

Reference yield:

ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) + 2-chloro-N,N-dimethylacetamide (2675-89-0) → (5S,6R)-4,5-dimethyl-6-phenylmorpholin-2-one (130753-28-5) + (1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide (130753-27-4)

Guidance literature:

With sodium carbonate; sodium iodide; In benzene; for 20h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jo00032a013

Reference yield: 88.0%

(1R,2S)-2-<(β-hydroxy-α-methylphenethyl)methylamino>-N,N-dimethylacetamide (130753-27-4) → (5S,6R)-4,5-dimethyl-6-phenylmorpholin-2-one (130753-28-5)

Guidance literature:

With sodium carbonate; In xylene; for 24h; Heating;

DOI:10.1021/jo00032a013

upstream raw materials:

ephedrine

2-chloro-N,N-dimethylacetamide

Downstream raw materials:

2-[((1S,2R)-2-Cyclohexylamino-1-methyl-2-phenyl-ethyl)-methyl-amino]-N,N-dimethyl-acetamide

(5S,6R)-4,5-dimethyl-6-phenylmorpholin-2-one

2-[((1S,2R)-2-Azido-1-methyl-2-phenyl-ethyl)-methyl-amino]-N,N-dimethyl-acetamide

2-[((1S,2R)-2-Butylamino-1-methyl-2-phenyl-ethyl)-methyl-amino]-N,N-dimethyl-acetamide

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