C₄₉H₆₂N₅O₁₅PSi

Base Information

• Chemical Name: C₄₉H₆₂N₅O₁₅PSi
• CAS No.: 349490-33-1
• Molecular Formula: C₄₉H₆₂N₅O₁₅PSi
• Molecular Weight: 1020.12
• Mol file: 349490-33-1.mol

Synonyms:C₄₉H₆₂N₅O₁₅PSi

Chemical Property of C₄₉H₆₂N₅O₁₅PSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₆₂N₅O₁₅PSi

There total 3 articles about C₄₉H₆₂N₅O₁₅PSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3′,5′-bis-O-[(tert-butyl)dimethylsilyl]-5,6-dihydrothymidine (187979-92-6) → C49H62N5O15PSi (349490-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sec-BuLi / tetrahydrofuran / -78 °C

1.2: DMPU; O₂ / tetrahydrofuran / 0.08 h

2.1: TFA / tetrahydrofuran; methanol / 1.5 h / 0 °C

3.1: tetrazole / acetonitrile / 2 h

3.2: I₂; 2,6-litidine; H₂₀

With 1H-tetrazole; sec.-butyllithium; trifluoroacetic acid; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/ja010180s

Reference yield:

1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-dihydro-pyrimidine-2,4-dione (349490-31-9) → C49H62N5O15PSi (349490-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TFA / tetrahydrofuran; methanol / 1.5 h / 0 °C

2.1: tetrazole / acetonitrile / 2 h

2.2: I₂; 2,6-litidine; H₂₀

With 1H-tetrazole; trifluoroacetic acid; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/ja010180s

Reference yield:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester (109389-30-2) + 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-dihydro-pyrimidine-2,4-dione (349490-32-0) → C49H62N5O15PSi (349490-33-1)

Guidance literature:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester; 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-dihydro-pyrimidine-2,4-dione; With 1H-tetrazole; In acetonitrile; for 2h;

With 2,6-dimethylpyridine; water; iodine; Further stages.;

DOI:10.1021/ja010180s

upstream raw materials:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-dihydro-pyrimidine-2,4-dione

3′,5′-bis-O-[(tert-butyl)dimethylsilyl]-5,6-dihydrothymidine

1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-dihydro-pyrimidine-2,4-dione

Refernces