(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

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Chemical Name:(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate
CAS No.:1578270-20-8
Molecular Formula:C₂₂H₂₄ClNO₄S
Molecular Weight:433.956
Hs Code.:

Synonyms:(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

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Chemical Property of (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

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Technology Process of (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

There total 7 articles about (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1578270-16-2
(R)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethanol

: 79-11-8
chloroacetic acid

: 1578270-20-8
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

: C₂₀H₂₁NO₂S

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2014.02.001

Reference yield:

: 1578270-14-0
(3S,5R)-3-allyl-5-phenyl-2-tosylisoxazolidine

: 1578270-20-8
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

: C₂₀H₂₁NO₂S

Guidance literature:: Multi-step reaction with 3 steps

1.1: molybdenum hexacarbonyl / water; acetonitrile / 0.25 h / 20 °C

1.2: 90 °C

2.1: dirhodium tetraacetate; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); hydrogen / tetrahydrofuran / 22 h / 65 °C / 3102.97 Torr / Sealed tube

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

With dirhodium tetraacetate; di-isopropyl azodicarboxylate; hydrogen; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); triphenylphosphine; molybdenum hexacarbonyl; In tetrahydrofuran; water; toluene; acetonitrile; 3.1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2014.02.001

Reference yield:

: 1578270-15-1
N-((1R,3S)-1-hydroxy-1-phenylhex-5-en-3-yl)-4-methylbenzenesulfonamide

: 1578270-20-8
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl 2-chloroacetate

: C₂₀H₂₁NO₂S

Guidance literature:: Multi-step reaction with 2 steps

1: triphenyl phosphite; dirhodium tetraacetate; hydrogen / tetrahydrofuran / 22 h / 65 °C / 3102.97 Torr / Sealed tube

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

With triphenyl phosphite; dirhodium tetraacetate; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; In tetrahydrofuran; toluene; 2: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2014.02.001