(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

Base Information

Chemical Name:(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate
CAS No.:1578270-30-0
Molecular Formula:C₂₂H₂₅NO₄S
Molecular Weight:399.511
Hs Code.:

Synonyms:(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

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Technology Process of (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

There total 3 articles about (S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1578270-18-4
(1S,3S,5S)-3-phenyl-9-tosyl-2-oxa-9-azabicyclo[3.3.1]nonane

: 108-24-7
acetic anhydride

: 1578270-30-0
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

Guidance literature:: With Amberlyst-A₁₅; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2014.02.001

Reference yield:

: 1578270-14-0
(3S,5R)-3-allyl-5-phenyl-2-tosylisoxazolidine

: 1578270-30-0
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: molybdenum hexacarbonyl / water; acetonitrile / 0.25 h / 20 °C

1.2: 90 °C

2.1: dirhodium tetraacetate; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); hydrogen / tetrahydrofuran / 22 h / 65 °C / 3102.97 Torr / Sealed tube

3.1: Amberlyst-A₁₅ / dichloromethane / 20 °C / Inert atmosphere

With dirhodium tetraacetate; hydrogen; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); molybdenum hexacarbonyl; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2014.02.001

Reference yield:

: 1578270-15-1
N-((1R,3S)-1-hydroxy-1-phenylhex-5-en-3-yl)-4-methylbenzenesulfonamide

: 1578270-30-0
(S)-1-phenyl-2-((S)-1-tosyl-1,2,3,4-tetrahydropyridin-2-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenyl phosphite; dirhodium tetraacetate; hydrogen / tetrahydrofuran / 22 h / 65 °C / 3102.97 Torr / Sealed tube

2: Amberlyst-A₁₅ / dichloromethane / 20 °C / Inert atmosphere

With triphenyl phosphite; dirhodium tetraacetate; hydrogen; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2014.02.001