2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

Base Information

Chemical Name:2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide
CAS No.:1373938-83-0
Molecular Formula:C₂₃H₁₉ClN₄O₃
Molecular Weight:434.882
Hs Code.:

Synonyms:2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

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Chemical Property of 2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

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Technology Process of 2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

There total 9 articles about 2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373939-83-3
3-(3-(5-aminopyrazin-2-yl)-4-methylphenyl)-5,5-dimethylisoxazol-4(5H)-one

: 609-65-4
o-chlorobenzoyl chloride

: 1373938-83-0
2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 15h;

Reference yield:

: 1373939-83-3
3-(3-(5-aminopyrazin-2-yl)-4-methylphenyl)-5,5-dimethylisoxazol-4(5H)-one

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1373938-83-0
2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.1c01403

Reference yield:

: 7697-26-9
3-bromo-4-methylbenzoic acid

: 1373938-83-0
2-chloro-N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3 h / 20 °C

2.1: tetrahydrofuran / -20 - 20 °C

2.2: 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

4.1: hydroxylamine hydrochloride; pyridine / methanol / 12 h / Reflux

5.1: chromium(VI) oxide; sulfuric acid / water; acetic acid / 0.5 h / 100 °C

6.1: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 100 °C / Inert atmosphere

7.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 15 h / 75 °C / Inert atmosphere

8.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

With pyridine; chromium(VI) oxide; sulfuric acid; hydroxylamine hydrochloride; potassium acetate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;