ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate

Base Information

• Chemical Name: ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate
• CAS No.: 1421674-23-8
• Molecular Formula: C₂₃H₁₉Cl₂N₃O₃S
• Molecular Weight: 488.394

Synonyms:ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate

Chemical Property of ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate

Chemical Property:

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Technology Process of ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate

There total 3 articles about ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-chlorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile (1421674-20-5) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate (1421674-23-8)

Guidance literature:

6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-chlorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloroacetic acid ethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.3390/molecules171113642

Reference yield:

1-(2-chloro-6-ethoxypyridin-4-yl)-3-(4-chlorophenyl)prop-2-en-1-one → ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate (1421674-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate / ethanol / 5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h / 60 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules171113642

Reference yield:

4-chlorobenzaldehyde (104-88-1) → ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-chlorophenyl)pyridin-2-ylthio)acetate (1421674-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; N,N-diethylaniline / ethanol / 6 h / Reflux

2.1: ammonium acetate / ethanol / 5 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 60 °C

With ammonium acetate; potassium carbonate; triethylamine; N,N-diethylaniline; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules171113642

upstream raw materials:

4-chlorobenzaldehyde

6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-chlorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile

chloroacetic acid ethyl ester

Downstream raw materials:

ethyl 3-amino-6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-chlorophenyl)thieno[2,3-b]pyridine-2-carboxylate

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