6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

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Chemical Name:6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride
CAS No.:1131216-30-2
Molecular Formula:C₂₆H₃₁N₃O₂*ClH
Molecular Weight:454.012
Hs Code.:

Synonyms:6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

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Chemical Property of 6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

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Technology Process of 6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

There total 7 articles about 6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 123-75-1
pyrrolidine

: 1131222-89-3
4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoic acid

: 1131216-30-2
6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

Guidance literature:: pyrrolidine; 4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

With hydrogenchloride; In diethyl ether; ethanol;

Reference yield: 42.0%

: 123-75-1
pyrrolidine

: 4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoyl chloride

: 1131216-30-2
6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

Guidance literature:: pyrrolidine; 4-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In diethyl ether; ethanol; water;
DOI:10.1021/jm300011d

Reference yield:

: 1131222-49-5
2-allyl-6-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1131216-30-2
6-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-2-(2-pyrrolidin-1-ylethyl)-3,4-dihydroiso-quinolin-1(2H)-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 0 °C

1.2: 8 h / 0 °C

2.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

3.1: dichlorobis(tri-O-tolylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 0.5 h / 90 °C

4.1: water; sodium hydroxide / ethanol / 3 h / 20 °C

5.1: thionyl chloride / 1 h / 65 °C

6.1: tetrahydrofuran / 1 h / 0 - 20 °C

With sodium periodate; thionyl chloride; dichlorobis(tri-O-tolylphosphine)palladium; water; sodium cyanoborohydride; potassium carbonate; acetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 3.1: Suzuki coupling;
DOI:10.1021/jm300011d