1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one

Base Information

• Chemical Name: 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one
• CAS No.: 261968-12-1
• Molecular Formula: C₁₈H₂₆O₄
• Molecular Weight: 306.402
• Mol file: 261968-12-1.mol

Synonyms:1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one

Chemical Property of 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one

There total 8 articles about 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methylpropenal (78-85-3,25120-30-3) + C26H41BO3 → 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one (261968-12-1)

Guidance literature:

2-methylpropenal; C₂₆H₄₁BO₃; In diethyl ether; at -20 ℃; for 21h;

With 30percent aq. H₂O₂; In methanol; at 0 - 20 ℃; pH=7; Further stages.;

DOI:10.1021/ja011211m

Reference yield:

C30H47BO4 → 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one (261968-12-1)

Guidance literature:

With water; dihydrogen peroxide; In methanol; at 0 ℃; for 2h; pH=7;

DOI:10.1002/(SICI)1521-3773(20000117)39:2<377::AID-ANIE377>3.0.CO;2-E

Reference yield:

(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one (182193-69-7) → 1-(p-methoxybenzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one (261968-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / diethyl ether / 1 h / 0 °C

2.1: diethyl ether / 21 h / -20 °C

2.2: 95 percent / 30percent aq. H₂O₂ / methanol / 0 - 20 °C / pH 7

With triethylamine; In diethyl ether;

DOI:10.1021/ja011211m

upstream raw materials:

2-methylpropenal

O-(4-methoxybenzyl)-trichloroacetimidate

methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

Downstream raw materials:

Propionic acid (1R,2R,3S,4S)-3-hydroxy-1-isopropenyl-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentyl ester

1-(p-methoxybenzyloxy)-3,5-dihydroxy-2,4,6-trimethyl-6-heptene

(2S,3R,4S,5Z,8R,9S,10R,11S,12S,13Z)-1,11-bis-(p-methoxybenzyloxy)-8-[(2,4,6-trimethylphenyl)sulfonyloxymethyl]-2,4,6,10,12-pentamethyl-hexadeca-5,13,15-trien-3,9-diol

tert-Butyl-{(Z)-(1R,2S)-5-{(2R,3R)-2-[(Z)-(1R,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-oxetan-3-yl}-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane