4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Base Information

Chemical Name:4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin
CAS No.:675199-75-4
Molecular Formula:C₂₄H₂₃N₃O₈
Molecular Weight:481.462
Hs Code.:

Synonyms:4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

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Chemical Property of 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

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Technology Process of 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

There total 3 articles about 4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 117604-05-4
4β-azido-4-deoxy-4′-demethylepipodophyllotoxin

: 107-19-7
propargyl alcohol

: 675199-75-4
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: With copper(ll) sulfate pentahydrate; L-ascorbic acid sodium salt; In water; tert-butyl alcohol; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.02.016

Reference yield:

: 6559-91-7
4'-demethylepipodophyllotoxin

: 675199-75-4
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; trifluoroacetic acid / chloroform / 1 h / 20 °C

2: ethanol; dichloromethane / 264 h / 70 - 80 °C

With sodium azide; trifluoroacetic acid; In ethanol; dichloromethane; chloroform;
DOI:10.1021/acs.jmedchem.5b00473

Reference yield:

: 518-28-5
podofilox

: 675199-75-4
4'-O-demethyl-4β-[(4-hydroxymethyl)-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide; methanesulfonic acid / dichloromethane / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: sodium azide; trifluoroacetic acid / chloroform / 1 h / 20 °C

3.1: ethanol; dichloromethane / 264 h / 70 - 80 °C

With sodium azide; methanesulfonic acid; trifluoroacetic acid; sodium iodide; In ethanol; dichloromethane; chloroform;
DOI:10.1021/acs.jmedchem.5b00473