4β-azido-4-deoxy-4′-demethylepipodophyllotoxin

Base Information

• Chemical Name: 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin
• CAS No.: 117604-05-4
• Molecular Formula: C₂₁H₁₉N₃O₇
• Molecular Weight: 425.398
• Mol file: 117604-05-4.mol

Synonyms:4β-azido-4-deoxy-4′-demethylepipodophyllotoxin

Chemical Property of 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin

There total 9 articles about 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4'-demethylepipodophyllotoxin (6559-91-7) → 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin (117604-05-4)

Guidance literature:

With sodium azide; trifluoroacetic acid; In chloroform; at 20 ℃;

Reference yield: 84.0%

4-demethylpodophyllotoxin (40505-27-9) → 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin (117604-05-4)

Guidance literature:

With sodium azide; trifluoroacetic acid; In chloroform; at 20 ℃; for 5h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.05.059

Reference yield: 60.0%

podofilox (518-28-5) → 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin (117604-05-4) + 4β-azido-4-deoxypodophyllotoxin (155252-34-9)

Guidance literature:

podofilox; With sodium iodide; In dichloromethane; for 0.0833333h;

With methanesulfonic acid; In dichloromethane; at 0 - 20 ℃; for 5h; Further stages; Inert atmosphere;

DOI:10.1080/14786419.2018.1538223

upstream raw materials:

4'-demethylepipodophyllotoxin

4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin

podofilox

4β-iodo-4-O-demethylpodophyllotoxin

Downstream raw materials:

C₄₁H₃₆N₂O₁₁

C₃₈H₃₀ClFN₂O₉

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one