7-amino-3-((5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Base Information

• Chemical Name: 7-amino-3-((5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
• CAS No.: 111298-82-9
• Molecular Formula: C₁₄H₁₅N₃O₅S₃
• Molecular Weight: 401.488
• Mol file: 111298-82-9.mol

Synonyms:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-,(6R-trans)-; TACS

Chemical Property of 7-amino-3-((5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Chemical Property:

• Boiling Point: 757.2±70.0 °C(Predicted)
• PKA: 2.40±0.50(Predicted)
• PSA: 212.66000
• Density: 1.72±0.1 g/cm3(Predicted)
• LogP: 1.39000

Purity/Quality:

99.9% ^*data from raw suppliers

TACS ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 42/43-52/53
• Safety Statements: 22-24-37-61

MSDS Files:

Useful:

• Uses: TACS can be used as reactant/reagent for synthesis, antibacterial activity, pharmacokinetics, and acute toxicity of cephalosporin derivatives containing thiomethyl substituted N-heterocycles and thiourea-acetamido groups.

Technology Process of 7-amino-3-((5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

There total 1 articles about 7-amino-3-((5-carboxymethyl-4-methyl-1,3-thiazol-2-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + 3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid → 7-β-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid (111298-82-9)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; In water;

upstream raw materials:

5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole

Refernces