34272-64-5

Basic information

• Product Name: 2-Mercapto-4-methyl-5-thiazoleacetic acid
• Synonyms: 2-mercapto-4-methyl-5-thiazoleaceticaci;2-MERCAPTO-4-METHYL-5-THIAZOLEACETIC ACID;2-MERCAPTO-4-METHYLTHIAZOLE-5-ACETIC ACID;MMTA;2,3-dihydro-4-methyl-2-thioxothiazol-5-acetic acid;2-MERCAPTO-4-METHYL-5-THIAZOLE ACETIC ACID(MMTA);2-mercapto-4-methylthiazole-5-yl acetic acid;2-Mercapto-4-Methyl-5-Thiazole
• CAS NO: 34272-64-5
• Molecular Formula: C₆H₇NO₂S₂
• Molecular Weight: 189.26
• EINECS: 251-905-4
• Product Categories: Organic acids;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 34272-64-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 207 °C (dec.)(lit.)
• Boiling Point: 363.4 °C at 760 mmHg
• Flash Point: 173.6 °C
• Appearance: white to light yellow crystal powder
• Density: 1.52 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.09±0.10(Predicted)
• CAS DataBase Reference: 2-Mercapto-4-methyl-5-thiazoleacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Mercapto-4-methyl-5-thiazoleacetic acid(34272-64-5)
• EPA Substance Registry System: 2-Mercapto-4-methyl-5-thiazoleacetic acid(34272-64-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3335
• WGK Germany: 3
• RTECS: XJ1921000
• Hazardous Substances Data: 34272-64-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2-Mercapto-4-methyl-5-thiazoleacetic acid may be used as a capping agent in the preparation of fused spherical gold nanoparticles. It may also be used in the synthesis of eight-tin macrocyclic complex (a 40-membered macrocycle containing two distannoxane ladders).

General Description

2-Mercapto-4-methyl-5-thiazoleacetic acid is a thiazole derivative. It participates in the preparation of dinuclear [Au-(O4NCS2)]2 and tetranuclear [Au(SSCOOH)]4 complexes.

Upstream product

• 86329-79-5 Kenicef 
• 99968-96-4 methyl 3-chlorolevulinate 
• 513-74-6 ammonium dithiocarbamate 
• 123-76-2 levulinic acid 
• 54260-84-3 ethyl 3-bromo-4-oxopentanoate 
• 111874-19-2 (4-methyl-2-thioxo-2,3-dihydro-thiazol-5-yl)-acetic acid ethyl ester 

Downstream Products

• 150535-74-3 (E)-5-<2-<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>ethenyl>-4-methyl-2(3H)-thiazolethione 
• 111298-82-9 7-β-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 

Relevant articles and documents

Method for synthesizing cefodizime sodium intermediate 2-mercapto-4-methyl-5-thiazoleacetic acid

The invention relates to a method for synthesizing a pharmaceutical intermediate, in particular to a method for synthesizing a cefodizime sodium intermediate 2-mercapto-4-methyl-5-thiazoleacetic acid.The method comprises the following steps of adding ammonium dithiocarbamate into an alkaline solvent, raising the temperature, dropwise adding 3-chloropropanoate, and conducting heat-preservation stirring; adding activated carbon for decolorization after dissolved clarification, conducting filtering, and conducting decompression distillation on obtained filtrate; washing and filtering solid products after the distillation with water, and conducting vacuum drying on remaining solid products to obtain 2-mercapto-4-methyl-5-thiazoleacetic acid. By means of the method, the product yield is greater than or equal to 60%, the product purity is greater than or equal to 99.5%, the production rate is obviously increased, the production cost is reduced, and the method meets the needs of industrial production.

Alkaline and neutral degradation of cefodizime (THR-221) and structural elucidation of the products. II

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