(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

Base Information

Chemical Name:(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide
CAS No.:1383802-51-4
Molecular Formula:C₂₀H₂₆F₃N₃OS
Molecular Weight:413.507
Hs Code.:

Synonyms:(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

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Chemical Property of (S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

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Technology Process of (S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

There total 1 articles about (S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-methyl-propane-2-sulfinic acid 1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-meth-(E)-ylideneamine

: 926-62-5
isobutylmagnesium bromide

: 1383802-51-4
(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

Guidance literature:: isobutylmagnesium bromide; With dimethyl zinc(II); In diethyl ether; toluene; at 20 ℃; for 0.583333h; Inert atmosphere;

(S)-2-methyl-propane-2-sulfinic acid 1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-meth-(E)-ylideneamine; In tetrahydrofuran; diethyl ether; toluene; at -78 - -72 ℃; for 2.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; toluene; at -70 - 5 ℃;

Reference yield: 97.0%

: 1383802-51-4
(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

: 1383802-54-7
(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; at 8 - 14 ℃;

Reference yield:

: 1383802-51-4
(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

: 1383802-45-6
3-[(6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-pyridine-3-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / diethyl ether; methanol / 8 - 14 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20.5 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 7 h / 50 - 60 °C

3.2: pH 5

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; ethyl acetate / 16 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.33 h / 20 °C

5.2: pH 5

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;