6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Base Information

Chemical Name:6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester
CAS No.:1383802-56-9
Molecular Formula:C₂₃H₂₃F₃N₄O₂
Molecular Weight:444.456
Hs Code.:

Synonyms:6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Suppliers and Price of 6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

There total 3 articles about 6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383802-54-7
(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamine hydrochloride

: 1427-06-1
methyl 6-fluoropyridine-3-carboxylate

: 1383802-56-9
6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 20.5h; Inert atmosphere;

Reference yield:

: 403-45-2
6-fluoronicotinic acid

: 1383802-56-9
6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20.5 h / 100 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 1383802-51-4
(S)-2-methyl-propane-2-sulfinic acid {(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butyl}-amide

: 1383802-56-9
6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; methanol / 8 - 14 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20.5 h / 100 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In methanol; diethyl ether; N,N-dimethyl-formamide;