ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

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Chemical Name:ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate
CAS No.:894794-67-3
Molecular Formula:C₂₅H₃₂ClN₅O₄
Molecular Weight:502.013
Hs Code.:

Synonyms:ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

There total 5 articles about ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 894794-68-4
C₂₁H₂₆ClN₅O₂

: 105-36-2
ethyl bromoacetate

: 894794-67-3
ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

Guidance literature:: With water; potassium carbonate; In 1-methyl-pyrrolidin-2-one; pentanonitrile; at 110 ℃; for 4h;
DOI:10.1016/j.tetlet.2011.03.080

Reference yield:

: 894794-69-5
N-(1-{(3R)-3-[(tert-Butoxycarbonyl)amino]-piperidin-1-yl}-2,2-dicyanovinyl)-N-(2-chlorobenzyl)glycine ethyl ester

: 894794-67-3
ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 894794-67-3
ethyl 3-amino-5-{(3R)-3-[(tert-butoxycarbonyl)-amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-cyano-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pentanonitrile / 1 h / 50 °C

2: potassium carbonate / pentanonitrile / 5 h / 130 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

4: lithium amide; tert-butyl alcohol / n-heptane; acetonitrile / 1 h / 20 °C

With lithium amide; potassium carbonate; tert-butyl alcohol; In n-heptane; pentanonitrile; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2011.03.080