3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

Base Information

Chemical Name:3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate
CAS No.:1362688-94-5
Molecular Formula:C₃₆H₄₇N₆O₈PS
Molecular Weight:754.844
Hs Code.:

Synonyms:3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

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Chemical Property of 3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

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Technology Process of 3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

There total 5 articles about 3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₅₅N₆O₁₀PS

: 1362688-94-5
3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

Guidance literature:: C₄₁H₅₅N₆O₁₀PS; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1362688-94-5
3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; hydrogenchloride; hydrogen sulfide; isobutyl chloroformate / tetrahydrofuran; water / -20 °C

2.1: sodium hydride / -20 - 20 °C

3.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

3.2: 40 - 50 °C

3.3: 80 - 100 °C

4.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

4.2: 0 - 5 °C / pH 7

With 4-methyl-morpholine; N,N'-dicyclohexyl-4-morpholine carboxamidine; hydrogenchloride; phosphoric acid; hydrogen sulfide; sodium hydride; isobutyl chloroformate; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 22410-97-5
(RS)-2-(4-benzoylphenyl)propanoic acid

: 1362688-94-5
3-({{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}[3-(L-isoleucylthio)propoxy]phosphoryl}oxy)propyl 2-(4-benzoylphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013