(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

Base Information

Chemical Name:(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one
CAS No.:1407547-45-8
Molecular Formula:C₂₃H₂₇NO
Molecular Weight:333.473
Hs Code.:

Synonyms:(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

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Chemical Property of (3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

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Technology Process of (3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

There total 6 articles about (3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1407547-42-5
(1S,2R)-2-{[(1R)-1-phenylethyl]amino}-1-[(E)-2-phenylethenyl]cyclohexanol

: 1407547-45-8
(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

Guidance literature:: With camphor-10-sulfonic acid; sodium sulfate; In dichloromethane; water; at 20 ℃; stereoselective reaction;
DOI:10.1021/jo301762a

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1407547-45-8
(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium; cerium(III) chloride / tetrahydrofuran / -78 °C

2: triethylamine; methanesulfonyl chloride / dichloromethane / -20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

4: lithium perchlorate / acetonitrile / 65 °C

5: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether / 2 h / 0 - 20 °C

6: camphor-10-sulfonic acid; sodium sulfate / water; dichloromethane / 20 °C

With n-butyllithium; cerium(III) chloride; camphor-10-sulfonic acid; lithium perchlorate; methanesulfonyl chloride; sodium sulfate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile; 6: |Mannich Aminomethylation;
DOI:10.1021/jo301762a

Reference yield:

: 1407547-38-9
(1S,2R)-2-{[(1R)-1-phenylethyl]amino}-1-(phenylethynyl)cyclohexanol

: 1407547-45-8
(3S,3aR,8aS)-3-phenyl-1-[(1R)-1-phenylethyl]octahydrocyclohepta[b]pyrrol-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / diethyl ether / 2 h / 0 - 20 °C

2: camphor-10-sulfonic acid; sodium sulfate / water; dichloromethane / 20 °C

With camphor-10-sulfonic acid; sodium sulfate; sodium bis(2-methoxyethoxy)aluminium dihydride; In diethyl ether; dichloromethane; water; 2: |Mannich Aminomethylation;
DOI:10.1021/jo301762a