rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Base Information

Chemical Name:rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1397683-73-6
Molecular Formula:C₁₃H₈BrF₃N₄O₃
Molecular Weight:405.131
Hs Code.:

Synonyms:rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Technology Process of rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 1 articles about rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1397683-72-5
C₁₅H₁₄BrF₃N₄O₄

: 1397683-73-6
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: C₁₅H₁₄BrF₃N₄O₄; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 150 ℃; for 0.5h; Sealed tube; Microwave irradiation;

With ammonium chloride; In dichloromethane; acetonitrile;

Reference yield: 94.0%

: 1397683-73-6
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

: 1397683-74-7
rac-2-amino-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: With hydrogen; ruthenium(IV) oxide; In methanol; at 50 ℃;

Reference yield:

: 1397683-73-6
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-2-nitro-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

: 1397683-75-8
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / ruthenium(IV) oxide / methanol / 50 °C

2.1: sulfuric acid / ethanol / 90 °C

2.2: 0.33 h / 90 °C

With sulfuric acid; hydrogen; ruthenium(IV) oxide; In methanol; ethanol;