2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)

Base Information

Chemical Name:2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)
CAS No.:111097-64-4
Molecular Formula:C₁₀H₁₉NO₃
Molecular Weight:201.266
Hs Code.:
Mol file:111097-64-4.mol

Synonyms:2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)

Suppliers and Price of 2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)

Chemical Property:

PSA：49.77000
LogP:0.53450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI)

There total 3 articles about 2-Pyrrolidinone,5-ethoxy-4-hydroxy-3-methyl-1-(1-methylethyl)-,[3S-(3alpha,4bta,5alpha)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111097-58-6
(S)-acetoxy-1-isopropylsuccinimide

: 111097-63-3,111097-64-4
(3S,4S)-5-Ethoxy-4-hydroxy-1-isopropyl-3-methyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaBH₄ 2.) H₂SO₄ / 1.) deg C, 15 min 2.)-25 deg C, 15 min, 1 h RT

2: NaOEt / ethanol

3: 1.) LDA / 1.) THF, -78 degC, 1h; -25 degC,1h 2.) -78 degC,1h

With sodium tetrahydroborate; sulfuric acid; lithium diisopropyl amide; sodium ethanolate; In ethanol;
DOI:10.1016/S0040-4039(01)81047-9

Reference yield:

: 608525-72-0
(4S,5RS)-4-acetoxy-5-ethoxy-1-isopropyl-2-pyrrolidinone

: 111097-63-3,111097-64-4
(3S,4S)-5-Ethoxy-4-hydroxy-1-isopropyl-3-methyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaOEt / ethanol

2: 1.) LDA / 1.) THF, -78 degC, 1h; -25 degC,1h 2.) -78 degC,1h

With lithium diisopropyl amide; sodium ethanolate; In ethanol;
DOI:10.1016/S0040-4039(01)81047-9

Reference yield:

: 111097-61-1,111097-62-2
(4S,5RS)-5-ethoxy-4-hydroxy-1-isopropyl-2-pyrrolidinone

: 74-88-4
methyl iodide

: 111097-63-3,111097-64-4
(3S,4S)-5-Ethoxy-4-hydroxy-1-isopropyl-3-methyl-pyrrolidin-2-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 degC, 1h; -25 degC,1h 2.) -78 degC,1h;
DOI:10.1016/S0040-4039(01)81047-9