(1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid

Base Information

• Chemical Name: (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid
• CAS No.: 1087347-35-0
• Molecular Formula: C₄₆H₅₈Cl₂N₂O₉
• Molecular Weight: 853.881
• Mol file: 1087347-35-0.mol

Synonyms:(1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid

Chemical Property of (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid

There total 26 articles about (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3R,4S)-3-({(cyclopropyl)[3-{[1-(2-methoxy-2-oxoethyl)cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2.,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate (1087347-34-9) → (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid (1087347-35-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 100 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane (877995-77-2) → (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid (1087347-35-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -70 °C

1.2: 1 h / -70 - 20 °C

1.3: 0.25 h

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol; water / 5 h / 80 °C

3.1: magnesium / methanol / 4.5 h / 20 °C / Heating / reflux

5.1: sodium hydroxide / ethanol; water / 18 h / Heating / reflux

5.2: 20 °C / pH < 1

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8.1: caesium carbonate / 18 h / 80 °C

9.1: sodium hydroxide / ethanol; water / 0.08 h / 100 °C / Microwave irradiation

With sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; water;

Reference yield:

3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde (1026786-84-4) → (1-{[3-{[[((3R,4S)-1-(tert-butoxycarbonyl)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl](cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenoxy]methyl}cyclopropyl)acetic acid (1087347-35-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2: magnesium sulfate / dichloromethane / 12 h / 20 °C

3: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

5: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: caesium carbonate / 18 h / 80 °C

8: sodium hydroxide / ethanol; water / 0.08 h / 100 °C / Microwave irradiation

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl (3R,4S)-3-({(cyclopropyl)[3-{[1-(2-methoxy-2-oxoethyl)cyclopropyl]methoxy}-5-(3-methoxypropyl)benzyl]amino}carbonyl)-4-{4-[2-(2.,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate

1-hydroxymethylcyclopropylacetic acid methyl ester

1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane

3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

Downstream raw materials:

tert-butyl (3R,4S)-3-{[[3-({1-[2-(benzyloxy)-2-oxoethyl]cyclopropyl}methoxy)-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]carbonyl}-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidine-1-carboxylate