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1026786-84-4

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1026786-84-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1026786-84-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,6,7,8 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1026786-84:
(9*1)+(8*0)+(7*2)+(6*6)+(5*7)+(4*8)+(3*6)+(2*8)+(1*4)=164
164 % 10 = 4
So 1026786-84-4 is a valid CAS Registry Number.

1026786-84-4Downstream Products

1026786-84-4Relevant articles and documents

The discovery and synthesis of potent zwitterionic inhibitors of renin

Aspiotis, Renee,Chen, Austin,Cauchon, Elizabeth,Dubé, Daniel,Falgueyret, Jean-Pierre,Gagné, Sébastien,Gallant, Michel,Grimm, Erich L.,Houle, Robert,Juteau, Hélne,Lacombe, Patrick,Laliberté, Sébastien,Lévesque, Jean-Franois,MacDonald, Dwight,McKay, Dan,Percival, M. David,Roy, Patrick,Soisson, Stephen M.,Wu, Tom

, p. 2430 - 2436 (2011)

The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-dependent inhibition and hERG affinity) relative to analogous non-zwitterionic inhibitors of the past (i.e., 3). Strategies to address the oral absorption of these zwitterions are also discussed within.

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

-

, (2009/12/27)

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well a

NOVEL CASE OF RENIN INHIBITORS

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, (2009/01/20)

The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.

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