tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate
• CAS No.: 1279088-72-0
• Molecular Formula: C₃₀H₂₉NO₃
• Molecular Weight: 451.565
• Mol file: 1279088-72-0.mol

Synonyms:tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate

Chemical Property of tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate

There total 2 articles about tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.2%

tert-butyl 1-(4-(phenylethynyl)phenyl)cyclobutylcarbamate (1032527-89-1) + ortho-bromobenzaldehyde (6630-33-7) → tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate (1279088-72-0)

Guidance literature:

With tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 48h;

Reference yield:

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate (1032350-06-3) → tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate (1279088-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: tetrabutyl-ammonium chloride; sodium acetate / palladium diacetate / N,N-dimethyl-formamide / 48 h / 100 °C

With copper(l) iodide; tetrabutyl-ammonium chloride; sodium acetate; N-ethyl-N,N-diisopropylamine; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield: 64.0%

tert-butyl 1-(4-(1-oxo-3-phenyl-1H-inden-2-yl)phenyl)cyclobutylcarbamate (1279088-72-0) → 2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-1H-inden-1-one hydrochloride (1279086-05-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

tert-butyl 1-(4-(phenylethynyl)phenyl)cyclobutylcarbamate

ortho-bromobenzaldehyde

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

Downstream raw materials:

2-(4-(1-aminocyclobutyl)phenyl)-3-phenyl-1H-inden-1-one hydrochloride