(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

Base Information

Chemical Name:(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one
CAS No.:140184-96-9
Molecular Formula:C₂₃H₃₂O₄
Molecular Weight:372.505
Hs Code.:

Synonyms:(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

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Chemical Property of (1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

Chemical Property:

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Technology Process of (1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

There total 7 articles about (1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140184-91-4
(1S,2S,4aR,7R,8aR)-7-[1-(4-Methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalene-2,8a-diol

: 140184-96-9
(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: With jones reagent; In acetone; at 0 ℃; Yield given;

Reference yield:

: 21683-08-9
(1R,4aR,7R,8aR)-8a-hydroxy-1,4a-dimethyl-7-(prop-1-en-2-yl)-octahydronaphthalen-2(1H)-one

: 140184-96-9
(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 79.2 percent / lithium aluminum hydride / tetrahydrofuran

2: 93.9 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

3: 95.3 percent / 80 percent m-chloroperbenzoic acid / CHCl₃ / 1 h / 0 - 5 °C

4: 88.2 percent / lithium diethylamide / diethyl ether / 8 h / Heating

5: 1. NaH / 1.) DMF, 2.) room temperature, 4 h

6: pyridinium p-toluenesulfonate / ethanol / 4 h / 70 °C

7: Jones reagent / acetone / 0 °C

With lithium aluminium tetrahydride; jones reagent; lithium diethylamide; pyridinium p-toluenesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetone;

Reference yield:

: 140184-90-3,73839-11-9
10-epieudesm-11-ene-3β,5α-diol

: 140184-96-9
(1R,4aR,7R,8aR)-8a-Hydroxy-7-[1-(4-methoxy-benzyloxymethyl)-vinyl]-1,4a-dimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 93.9 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

2: 95.3 percent / 80 percent m-chloroperbenzoic acid / CHCl₃ / 1 h / 0 - 5 °C

3: 88.2 percent / lithium diethylamide / diethyl ether / 8 h / Heating

4: 1. NaH / 1.) DMF, 2.) room temperature, 4 h

5: pyridinium p-toluenesulfonate / ethanol / 4 h / 70 °C

6: Jones reagent / acetone / 0 °C

With jones reagent; lithium diethylamide; pyridinium p-toluenesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; dichloromethane; chloroform; acetone;