1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine
CAS No.:407629-69-0
Molecular Formula:C₂₁H₁₅F₄N₃
Molecular Weight:385.364
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

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Chemical Property of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

Chemical Property:

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Technology Process of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

There total 9 articles about 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 327619-54-5
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

: 407629-69-0
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

Guidance literature:: With acetic acid; zinc; at 20 ℃; for 1h;
DOI:10.1021/jm060103d

Reference yield:

: 212503-82-7
methyl N,N-bis(2,6-difluorobenzoyl)-3-nitro-2-anilinecarboxylate

: 407629-69-0
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / pyridine; NH₂NH₂ / 6 h / 20 °C

2: 60 percent / LiAlH₄ / tetrahydrofuran / 4 h / 0 - 20 °C

3: 75 percent / Et₃N / tetrahydrofuran / 20 °C

4: 75 percent / Fe; AcOH / 0.5 h / Heating

5: 76 percent / NaH / tetrahydrofuran / 6 h

6: 96 percent / K₂CO₃ / methanol; H₂O / 0.5 h

7: 92 percent / SOCl₂ / CHCl₃ / 3 h / 20 °C

8: 93 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

9: 31 percent / Zn; AcOH / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; sodium azide; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; hydrazine; zinc; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060103d

Reference yield:

: 212503-83-8
methyl N-(2,6-difluorobenzoyl)-3-nitro-2-anilinecarboxylate

: 407629-69-0
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazol-4-yl-methylamine

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / LiAlH₄ / tetrahydrofuran / 4 h / 0 - 20 °C

2: 75 percent / Et₃N / tetrahydrofuran / 20 °C

3: 75 percent / Fe; AcOH / 0.5 h / Heating

4: 76 percent / NaH / tetrahydrofuran / 6 h

5: 96 percent / K₂CO₃ / methanol; H₂O / 0.5 h

6: 92 percent / SOCl₂ / CHCl₃ / 3 h / 20 °C

7: 93 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

8: 31 percent / Zn; AcOH / 1 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium azide; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060103d