1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole
CAS No.:327619-54-5
Molecular Formula:C₂₁H₁₃F₄N₅
Molecular Weight:411.361
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

Chemical Property:

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Technology Process of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

There total 8 articles about 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 327619-53-4
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-chloromethylbenzimidazole

: 327619-54-5
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm060103d

Reference yield:

: 212503-82-7
methyl N,N-bis(2,6-difluorobenzoyl)-3-nitro-2-anilinecarboxylate

: 327619-54-5
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / pyridine; NH₂NH₂ / 6 h / 20 °C

2: 60 percent / LiAlH₄ / tetrahydrofuran / 4 h / 0 - 20 °C

3: 75 percent / Et₃N / tetrahydrofuran / 20 °C

4: 75 percent / Fe; AcOH / 0.5 h / Heating

5: 76 percent / NaH / tetrahydrofuran / 6 h

6: 96 percent / K₂CO₃ / methanol; H₂O / 0.5 h

7: 92 percent / SOCl₂ / CHCl₃ / 3 h / 20 °C

8: 93 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; sodium azide; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; hydrazine; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060103d

Reference yield:

: 327619-44-3
2,6-difluorobenzoic acid 2-acetoxymethyl-6-nitroanilide

: 327619-54-5
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyleneazidobenzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / Fe; AcOH / 0.5 h / Heating

2: 76 percent / NaH / tetrahydrofuran / 6 h

3: 96 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 92 percent / SOCl₂ / CHCl₃ / 3 h / 20 °C

5: 93 percent / NaN₃ / dimethylformamide / 1 h / 20 °C

With thionyl chloride; sodium azide; iron; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060103d