Technology Process of METHYL 3-OXO-6-OCTENOATE
There total 4 articles about METHYL 3-OXO-6-OCTENOATE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetoacetic acid methyl ester;
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.333333h;
(E)-1-Bromo-2-butene;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/acs.jmedchem.8b00007
- Guidance literature:
-
ethyl acetoacetate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.166667h;
With
n-butyllithium;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.166667h;
(E/Z)-crotyl bromide;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/ol503541z
- Guidance literature:
-
acetoacetic acid methyl ester;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
n-butyllithium;
In
tetrahydrofuran; n-heptane; mineral oil;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
crotonyl bromide;
In
tetrahydrofuran; n-heptane; mineral oil;
at 20 ℃;
for 2h;
Inert atmosphere;
