(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

Base Information

Chemical Name:(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate
CAS No.:1383005-31-9
Molecular Formula:C₂HF₃O₂*C₂₇H₃₁N₃O₅
Molecular Weight:591.584
Hs Code.:

Synonyms:(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

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Chemical Property of (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

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Technology Process of (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

There total 10 articles about (2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-acetyl-1H-pyrazole-5-carboxylic acid

: 1383027-21-1
(2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester hydrochloride

: 76-05-1
trifluoroacetic acid

: 1383005-31-9
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

Guidance literature:: 3-acetyl-1H-pyrazole-5-carboxylic acid; (2R,4R)-4-amino-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid;

Reference yield:

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

: 1383005-31-9
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3 h / -5 °C

2.1: toluene / 3 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

4.2: 1 h / -78 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

5.2: 0.5 h

6.1: hydrogenchloride / water / 20 h / 90 - 95 °C

7.1: acetyl chloride / Cooling with ice

7.2: 3 h / 80 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With hydrogenchloride; n-butyllithium; sodium hexamethyldisilazane; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; In tetrahydrofuran; hexanes; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383005-31-9
(2R,4R)-4-[(5-acetyl-2H-pyrazole-3-carbonyl)amino]-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -65 °C / Inert atmosphere

4.2: 2 h / -35 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 2.25 h / 0 °C

6.1: potassium carbonate / 20 h / 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol / 3 h / 25 °C

8.1: acetyl chloride / Cooling with ice

8.2: 3 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With dmap; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;