3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Base Information

Chemical Name:3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
CAS No.:1446685-13-7
Molecular Formula:C₃₅H₄₄FN₃O₇S
Molecular Weight:669.815
Hs Code.:

Synonyms:3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

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Chemical Property of 3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

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Technology Process of 3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

There total 5 articles about 3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1446685-09-1
3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

: 98-59-9
p-toluenesulfonyl chloride

: 1446685-13-7
3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 10 - 20 ℃; for 3h;
DOI:10.1021/jo400646k

Reference yield:

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1446685-13-7
3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

2: potassium hydroxide / N,N-dimethyl-formamide / 20 h / 110 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 3 h / 10 - 20 °C

With dmap; triethylamine; diisopropylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo400646k

Reference yield:

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 1446685-13-7
3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.5 h / 20 °C

1.2: 1.5 h / 0 - 20 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 20 h / 110 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 3 h / 10 - 20 °C

With dmap; triethylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo400646k