3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Base Information

• Chemical Name: 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
• CAS No.: 1446685-09-1
• Molecular Formula: C₂₈H₃₈FN₃O₅
• Molecular Weight: 515.625

Synonyms:3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Chemical Property of 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

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Technology Process of 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

There total 4 articles about 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

8-tosyloxy-3,6-dioxaoctanol (77544-68-4) + Spiramide (510-74-7) → 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446685-09-1)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 110 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jo400646k

Reference yield:

1-(3-chloropropoxy)-4-fluorobenzene (1716-42-3) → 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446685-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylamine / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

2: potassium hydroxide / N,N-dimethyl-formamide / 20 h / 110 °C / Inert atmosphere

With diisopropylamine; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jo400646k

Reference yield:

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (1021-25-6) → 3-[2-(2-(2-hydroxyethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446685-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylamine / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

2: potassium hydroxide / N,N-dimethyl-formamide / 20 h / 110 °C / Inert atmosphere

With diisopropylamine; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jo400646k

upstream raw materials:

8-tosyloxy-3,6-dioxaoctanol

Spiramide

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

1-(3-chloropropoxy)-4-fluorobenzene

Downstream raw materials:

3-[2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethyl]-8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

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