4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

Base Information

Chemical Name:4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one
CAS No.:110690-93-2
Molecular Formula:C10H9 Cl F2 O
Molecular Weight:218.631
Hs Code.:
DSSTox Substance ID:DTXSID60548110
Mol file:110690-93-2.mol

Synonyms:110690-93-2;4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one;1-Butanone, 4-chloro-2-fluoro-1-(4-fluorophenyl)- (9CI);SCHEMBL15194607;DTXSID60548110;KHCFOACJRBWOAT-UHFFFAOYSA-N

Suppliers and Price of 4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

Chemical Property:

PSA：17.07000
LogP:2.97540
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:218.0309989
Heavy Atom Count:14
Complexity:191

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)C(CCCl)F)F

Technology Process of 4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

There total 1 articles about 4-Chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 110690-93-2
4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

Guidance literature:: 4-(4-fluorophenyl)-4-oxo-n-butyl chloride; With bromine; In 1,4-dioxane; at 20 ℃;

With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 47.0%

: 110690-93-2
4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

: 103543-82-4
(1-fluorocyclopropyl)(4-fluorophenyl)methanone

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 110690-93-2
4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

: 1588766-55-5
2-bromo-4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

Guidance literature:: 4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one; With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ja501815p