(1-Fluorocyclopropyl)(4-fluorophenyl)methanone

Base Information

Chemical Name:(1-Fluorocyclopropyl)(4-fluorophenyl)methanone
CAS No.:103543-82-4
Molecular Formula:C10H8 F2 O
Molecular Weight:182.17
Hs Code.:
DSSTox Substance ID:DTXSID00545986
Wikidata:Q82423657
Mol file:103543-82-4.mol

Synonyms:103543-82-4;(1-Fluorocyclopropyl)(4-fluorophenyl)methanone;SCHEMBL10524449;DTXSID00545986

Suppliers and Price of (1-Fluorocyclopropyl)(4-fluorophenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (1-Fluorocyclopropyl)(4-fluorophenyl)methanone

Chemical Property:

Boiling Point:240.6±20.0 °C(Predicted)
PSA：17.07000
Density:1.26±0.1 g/cm3(Predicted)
LogP:2.51050
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:182.05432120
Heavy Atom Count:13
Complexity:215

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1(C(=O)C2=CC=C(C=C2)F)F

Technology Process of (1-Fluorocyclopropyl)(4-fluorophenyl)methanone

There total 2 articles about (1-Fluorocyclopropyl)(4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 110690-93-2
4-chloro-2-fluoro-1-(4-fluorophenyl)butan-1-one

: 103543-82-4
(1-fluorocyclopropyl)(4-fluorophenyl)methanone

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 103543-82-4
(1-fluorocyclopropyl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine / 1,4-dioxane / 20 °C

1.2: 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

With bromine; sodium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;