N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide

Base Information

Chemical Name:N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide
CAS No.:874909-61-2
Molecular Formula:C₁₄H₁₉ClFN₃O₅S
Molecular Weight:395.839
Hs Code.:
DSSTox Substance ID:DTXSID201343334

Synonyms:N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide;N-[2-chloro-4-fluoro-5-{(ethoxycarbonyl)amino}benzoyl]-N'-isopropyl-N'-methylsulfamide;SCHEMBL709376;DTXSID201343334;874909-61-2;N-[2-chloro-4-fluoro-5-{(ethoxycarbonyl)-amino}benzoyl]-N'-isopropyl-N'-methylsulfamide;N-[4-Chloro-2-fluoro-5-[[[[methyl(1-methylethyl)amino]sulfonyl]amino]carbonyl]phenyl]carbamic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:395.0717977
Heavy Atom Count:25
Complexity:584

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)NC1=C(C=C(C(=C1)C(=O)NS(=O)(=O)N(C)C(C)C)Cl)F

Technology Process of N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide

There total 2 articles about N-(2-chloro-4-fluoro-5-[(ethoxycarbonyl)amino]benzoyl)-N'-isopropyl-N'-methylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 685568-49-4
N-(5-amino-2-chloro-4-fluoro-benzoyl)-N'-methyl-N'-isopropylsulfamide

: 541-41-3
chloroformic acid ethyl ester

: 874909-61-2
N-{6-chloro-4-fluoro-3-[(ethoxycarbonyl)-amino]-benzoyl}-N'-iso-propyl-N'-methylsulfamide

Guidance literature:: In toluene; at 105 - 110 ℃; for 6.5h; Product distribution / selectivity;

Reference yield: 71.0%

: 874909-59-8
N-{4-fluoro-3-[(ethoxycarbonyl)-amino]-benzoyl}-N'-iso-propyl-N'-methylsulfamide

: 874909-61-2
N-{6-chloro-4-fluoro-3-[(ethoxycarbonyl)-amino]-benzoyl}-N'-iso-propyl-N'-methylsulfamide

Guidance literature:: With sulfuryl dichloride; In chlorobenzene; at 40 - 65 ℃; for 10 - 16h; Product distribution / selectivity;

Reference yield: 92.7%

: 874909-61-2
N-{6-chloro-4-fluoro-3-[(ethoxycarbonyl)-amino]-benzoyl}-N'-iso-propyl-N'-methylsulfamide

: 372-29-2,141860-78-8
ethyl 3-amino-4,4,4-trifluoro-2-butenoate

: 854122-75-1
2-chloro-5-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluoro-N-{[methyl(1-methylethyl)amino]sulfonyl}-benzamide

Guidance literature:: ethyl 3-amino-4,4,4-trifluoro-2-butenoate; With potassium methanolate; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-{6-chloro-4-fluoro-3-[(ethoxycarbonyl)-amino]-benzoyl}-N'-iso-propyl-N'-methylsulfamide; In methanol; N,N-dimethyl-formamide; at 20 - 119 ℃; Product distribution / selectivity;