((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine

Base Information

• Chemical Name: ((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine
• CAS No.: 296241-66-2
• Molecular Formula: C₂₃H₃₁NO
• Molecular Weight: 337.505
• Mol file: 296241-66-2.mol

Synonyms:((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine

Chemical Property of ((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine

There total 1 articles about ((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(prop-2-ene-1,1-diylbis(oxy))bis(methylene)dibenzene (40575-57-3) + [3-Methyl-but-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine → ((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine (296241-66-2)

Guidance literature:

(prop-2-ene-1,1-diylbis(oxy))bis(methylene)dibenzene; With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether; at -50 - -40 ℃; for 1.5h;

[3-Methyl-but-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine; In diethyl ether; at -40 - 20 ℃; for 8h;

DOI:10.1016/S0040-4039(00)00882-0

Reference yield:

((1R,2R)-2-Benzyloxy-1-isobutyl-but-3-enyl)-((R)-1-phenyl-ethyl)-amine (296241-66-2) → ((1R,2R)-2-Benzyloxy-4-hydroxy-1-isobutyl-butyl)-((R)-1-phenyl-ethyl)-carbamic acid methyl ester (296241-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / tetrahydrofuran

2.1: 9-BBN / tetrahydrofuran

2.2: H₂O₂; NaHCO₃ / H₂O

With 9-borabicyclo[3.3.1]nonane dimer; potassium carbonate; In tetrahydrofuran; 1.1: Condensation / 2.1: Substitution / 2.2: Oxidation;

DOI:10.1016/S0040-4039(00)00882-0

upstream raw materials:

(prop-2-ene-1,1-diylbis(oxy))bis(methylene)dibenzene

Downstream raw materials:

((1R,2R)-2-Benzyloxy-4-hydroxy-1-isobutyl-butyl)-((R)-1-phenyl-ethyl)-carbamic acid methyl ester