Technology Process of ethyl (S,E)-2-(3,5-bis(benzyloxy)-2-(6-(benzyloxy)oct-2-enoyl)phenyl)ethanoate
There total 7 articles about ethyl (S,E)-2-(3,5-bis(benzyloxy)-2-(6-(benzyloxy)oct-2-enoyl)phenyl)ethanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
4: lithium tetrafluoroborate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere
5: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 0.5 h / 0 °C / Inert atmosphere
6: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium chlorite; lithium tetrafluoroborate; tetrapropylammonium perruthennate; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; caesium carbonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2012.06.009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium triethylborohydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
3: lithium tetrafluoroborate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere
4: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 0.5 h / 0 °C / Inert atmosphere
5: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium chlorite; lithium tetrafluoroborate; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; lithium triethylborohydride; caesium carbonate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2012.06.009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 45 °C / Inert atmosphere
2: lithium tetrafluoroborate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere
3: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 0.5 h / 0 °C / Inert atmosphere
4: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium chlorite; lithium tetrafluoroborate; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; caesium carbonate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2012.06.009
