ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

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Chemical Name:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate
CAS No.:1402145-34-9
Molecular Formula:C₂₈H₃₁F₃N₂O₄
Molecular Weight:516.56
Hs Code.:

Synonyms:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

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Chemical Property of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

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Technology Process of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

There total 4 articles about ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 540-88-5
acetic acid tert-butyl ester

: 1402145-33-8
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

: 1402145-34-9
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

Guidance literature:: With perchloric acid; at 0 - 20 ℃; for 1h;

Reference yield:

: 119-84-6,1341-36-2
C₆H₄(CH₂CH₂C(O)O)

: 1402145-34-9
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc; acetic acid / 15 h / 100 °C

2.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

2.2: 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: acetonitrile / 16 h / Reflux

5.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

6.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

6.2: 1 h / -20 °C

7.1: sodium tetrahydroborate / methanol / 2 h / Inert atmosphere

8.1: perchloric acid / 1 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; perchloric acid; isopropylmagnesium chloride; sodium hydride; acetic acid; Ethyl oxalyl chloride; zinc; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 493-08-3
chromane

: 1402145-34-9
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

1.2: 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: acetonitrile / 16 h / Reflux

4.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

5.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

5.2: 1 h / -20 °C

6.1: sodium tetrahydroborate / methanol / 2 h / Inert atmosphere

7.1: perchloric acid / 1 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; perchloric acid; isopropylmagnesium chloride; sodium hydride; Ethyl oxalyl chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;