ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

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Chemical Name:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate
CAS No.:1402145-33-8
Molecular Formula:C₂₄H₂₃F₃N₂O₄
Molecular Weight:460.453
Hs Code.:

Synonyms:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

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Chemical Property of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

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Technology Process of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

There total 4 articles about ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1402145-32-7
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

: 1402145-33-8
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

Guidance literature:: ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate; With sodium tetrahydroborate; In methanol; for 2h; Inert atmosphere;

With water;

Reference yield:

: 119-84-6,1341-36-2
C₆H₄(CH₂CH₂C(O)O)

: 1402145-33-8
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; acetic acid / 15 h / 100 °C

2.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

2.2: 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: acetonitrile / 16 h / Reflux

5.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

6.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

6.2: 1 h / -20 °C

7.1: sodium tetrahydroborate / methanol / 2 h / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; isopropylmagnesium chloride; sodium hydride; acetic acid; Ethyl oxalyl chloride; zinc; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 493-08-3
chromane

: 1402145-33-8
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

1.2: 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: acetonitrile / 16 h / Reflux

4.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

5.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

5.2: 1 h / -20 °C

6.1: sodium tetrahydroborate / methanol / 2 h / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; isopropylmagnesium chloride; sodium hydride; Ethyl oxalyl chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;