trans-3,5-dimethoxycinnamoyl chloride

Base Information

• Chemical Name: trans-3,5-dimethoxycinnamoyl chloride
• CAS No.: 195617-72-2
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Mol file: 195617-72-2.mol

Synonyms:trans-3,5-dimethoxycinnamoyl chloride

Chemical Property of trans-3,5-dimethoxycinnamoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3,5-dimethoxycinnamoyl chloride

There total 3 articles about trans-3,5-dimethoxycinnamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3,5-dimethoxycinnamic acid (20767-04-8) → trans-3,5-dimethoxycinnamoyl chloride (195617-72-2)

Guidance literature:

With thionyl chloride; In dichloromethane; for 3h; Heating / reflux;

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → trans-3,5-dimethoxycinnamoyl chloride (195617-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; piperidine / 90 °C

2: oxalyl dichloride / dichloromethane / 20 °C

With piperidine; pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.2174/1570180811666140812231519

Reference yield:

3-(3,5-dimethoxyphenyl)acrylic acid (16909-11-8) → (Z)-3-(3,5-dimethoxyphenyl)propenoyl chloride + trans-3,5-dimethoxycinnamoyl chloride (195617-72-2)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 3h; Title compound not separated from byproducts;

upstream raw materials:

3-(3,5-dimethoxyphenyl)acrylic acid

(E)-3,5-dimethoxycinnamic acid

3,5-dimethoxybenzaldehdye

Downstream raw materials:

trans-3,5-dimethoxycinnamic acyl azide

3-[(2E)-3-(3,5-dimethoxyphenyl)prop-2-enoyl]-1,3-bis[(4-chloro-3-trifluoromethyl)phenyl]triazene

3-[(2E)-3-(3,5-dimethoxyphenyl)prop-2-enoyl]-1,3-bis[2-chloro-5-trifluoromethylphenyl]triazene

C₁₈H₂₀N₂O₃S

Refernces

• 1、 Yao, Ri-Sheng,Guan, Qiu-Xiang,Lu, Xiao-Qin,Ruan, Ban-Feng. "Design, synthesis and cytotoxic evaluation of novel imatinib amide derivatives that target Abl kinase". . p. 20 - 28. Retrieved 2015/03/31.
• 2、 Jamie, Joanne F.,Rickards, Rodney W.. "Radical-mediated cyclisation of ω-aryl-β-dicarbonyl compounds to tetrahydrobenzocyclohepten-6-ones, hexahydrobenzocycloocten-6-ones and naphthalen-2(1H)-ones". . p. 3613 - 3621. Retrieved 2007/10/03.