N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

Base Information

Chemical Name:N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide
CAS No.:1084926-27-1
Molecular Formula:C₂₃H₂₈N₄O₂
Molecular Weight:392.501
Hs Code.:

Synonyms:N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

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Chemical Property of N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

Chemical Property:

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Technology Process of N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

There total 4 articles about N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: N-(4-cyano-piperidin-4-yl)-5-methyl-nicotinamide dihydrochloride

: 157143-20-9
3-Ethoxy-4-methylbenzaldehyd

: 1084926-27-1
N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

Guidance literature:: With titanium(IV)isopropoxide; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;

Reference yield:

: 1084926-72-6
4-cyano-4-[(5-methyl-pyridine-3-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

: 1084926-27-1
N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: Ti(O-i-Pr)4; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine / isopropyl alcohol

With hydrogenchloride; Ti(O-i-Pr)4; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 331281-25-5
4-amino-4-cyano-piperidine-1-carboxylic acid tert-butyl ester

: 1084926-27-1
N-[4-cyano-1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-yl]-5-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 40 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: Ti(O-i-Pr)4; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine / isopropyl alcohol

With hydrogenchloride; Ti(O-i-Pr)4; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;