20R-Camptothecin

Base Information

Chemical Name:20R-Camptothecin
CAS No.:110351-92-3
Molecular Formula:C20H16 N2 O4
Molecular Weight:348.358
Hs Code.:
Mol file:110351-92-3.mol

Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-, (R)-; (R)-(-)-Camptothecin; (R)-(-)-Camptothecine;(R)-Camptothecin; 20R-Camptothecin

Suppliers and Price of 20R-Camptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(-)-Camptothecin
10mg
$ 16540.00

American Custom Chemicals Corporation
(R)-(-)-CAMPTOTHECIN 95.00%
10MG
$ 18768.75

Total 9 raw suppliers

Chemical Property of 20R-Camptothecin

Chemical Property:

Vapor Pressure:4.39E-24mmHg at 25°C
Refractive Index:1.746
Boiling Point:757°Cat760mmHg
PKA:11.24±0.20(Predicted)
Flash Point:411.6°C
PSA：81.42000
Density:1.51g/cm³
LogP:2.07960

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-Camptothecin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.

Technology Process of 20R-Camptothecin

There total 54 articles about 20R-Camptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 529-23-7
o-aminobenzaldehyde

: 110351-91-2
5'(R)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano<3',4'-f>Δ^6,8-tetrahydroindolizine

: 110351-92-3,91926-09-9
(R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 1h; Heating;
DOI:10.1021/jm00395a024

Reference yield: 71.0%

: 841276-70-8
4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

: 110351-92-3,91926-09-9
(R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione

: 7689-03-4,91926-09-9
camptothecin

Guidance literature:: 4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one; With methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium dioxotetrahydroxoosmate(VI); In water; tert-butyl alcohol; at 0 ℃; for 40h;

With iodine; calcium carbonate; In methanol; water; at 40 ℃; for 15h; Further stages.;
DOI:10.1021/ol0706307

Reference yield:

: 34141-35-0
4-ethyl-1,12-dihydro-14-H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione

: 110351-92-3,91926-09-9
(R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione

: 7689-03-4,91926-09-9
camptothecin

Guidance literature:: 4-ethyl-1,12-dihydro-14-H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione; With (+)-[(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; at 20 ℃; for 19h;

With water; Overall yield = 32 %; Overall yield = 5 mg;
DOI:10.1007/s10593-017-2070-4