2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol

Base Information

• Chemical Name: 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol
• CAS No.: 1314025-65-4
• Molecular Formula: C₃₅H₄₂N₂O₄
• Molecular Weight: 554.729

Synonyms:2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol

Chemical Property of 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol

Chemical Property:

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Technology Process of 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol

There total 2 articles about 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-((3-(((2-hydroxyethyl)methylamino)methyl)benzyl)methylamino)ethanol (59406-93-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol (1314025-65-4)

Guidance literature:

With pyridine; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1ob05085k

Reference yield:

1,3-bis-(bromomethyl)benzene (626-15-3) → 2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol (1314025-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 22 h / Reflux

2: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; sodium carbonate; In acetonitrile;

DOI:10.1039/c1ob05085k

Reference yield: 36.0%

2-((3-(((2-(4,4'-dimethoxytrityloxy)ethyl)methylamino)methyl)benzyl)methylamino)ethanol (1314025-65-4) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → (3-(((2-((2-cyanoethyl)(diisopropylamino)phosphinoxy)ethyl)methylamino)methyl)benzyl)-(2-(4,4'-dimethoxytrityloxy)ethyl)methylamine (1314025-68-7)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1ob05085k

upstream raw materials:

2-((3-(((2-hydroxyethyl)methylamino)methyl)benzyl)methylamino)ethanol

4,4'-dimethoxytrityl chloride

1,3-bis-(bromomethyl)benzene

Downstream raw materials:

(3-(((2-((2-cyanoethyl)(diisopropylamino)phosphinoxy)ethyl)methylamino)methyl)benzyl)-(2-(4,4'-dimethoxytrityloxy)ethyl)methylamine

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