trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

Base Information

Chemical Name:trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride
CAS No.:1402911-34-5
Molecular Formula:C₁₉H₁₇F₄N₃O*ClH
Molecular Weight:415.818
Hs Code.:

Synonyms:trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

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Chemical Property of trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

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Technology Process of trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

There total 2 articles about trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: trans-3-((4-fluoro-3-(trifluoromethyl)phenyl)oxy)cyclobutanamine hydrochloride

: 136117-74-3
8-imidazo<1,2-a>pyridinecarboxaldehyde

: 1402911-34-5
trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

Guidance literature:: trans-3-((4-fluoro-3-(trifluoromethyl)phenyl)oxy)cyclobutanamine hydrochloride; 8-imidazo<1,2-a>pyridinecarboxaldehyde; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 61721-07-1
4-fluoro-3-(trifluoromethyl)phenol

: 1402911-34-5
trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: cyanomethylenetributyl-phosphorane / toluene / 100 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Sealed vessel

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; In 1,4-dioxane; dichloromethane; toluene;