61721-07-1

Basic information

• Product Name: 4-Fluoro-3-(trifluoromethyl)phenol
• Synonyms: 2-FLUORO-5-HYDROXYBENZOTRIFLUORIDE;4-FLUORO-3-(TRIFLUOROMETHYL)PHENOL;3-Trifluoromethyl-4-Fluoro Phenol 3-Trifluoromethyl-4-Fluorophenol;3-Trifluoromethyl-4-fluorophenol;alpha,alpha,alpha-4-Tetrafluoro-m-cresol;4-Fluoro-3-trifluoromethyl;à,à,à-4-tetrafluoro-m-cresol;4-Fluoro-3-(trifluoromethyl)phenol 98%
• CAS NO: 61721-07-1
• Molecular Formula: C₇H₄F₄O
• Molecular Weight: 180.1
• EINECS: 432-560-0
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan
• Mol File: 61721-07-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 17 °C
• Boiling Point: 84-86°C 15mm
• Flash Point: 90°C
• Appearance: /
• Density: 1.145
• Vapor Pressure: 0.164mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.97±0.18(Predicted)
• BRN: 2098736
• CAS DataBase Reference: 4-Fluoro-3-(trifluoromethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-(trifluoromethyl)phenol(61721-07-1)
• EPA Substance Registry System: 4-Fluoro-3-(trifluoromethyl)phenol(61721-07-1)

Safety Data

• Hazard Codes: T,Xn
• Statements: 22-34-36/37/38-20/21/22
• Safety Statements: 23-26-28-36/37/39-45
• RIDADR: 2922
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 61721-07-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to pale yellow liquid

Uses

4-Fluoro-3-trifluoromethylphenol

InChI:InChI=1/C7H4F4O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H

Upstream product

• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 

Downstream Products

• 361377-26-6 4-chloro-5-fluoro-6-[4-fluoro-3-(trifluoromethyl)phenoxy]pyrimidine 
• 254895-18-6 6-[(α,α,α,4-Tetrafluoro-m-tolyl)oxy]-4-pyrimidinyl α,α,α,-trifluoro-m-tolyl ketone 
• 289-95-2 PYRIMIDINE 
• 1363132-76-6 2-{8-[4-fluoro-3-(trifluoromethyl)phenoxy]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol 
• 113614-08-7 (S)-2-[4-fluoro-3-(trifluoromethyl)phenoxy]-N-(phenylmethyl)butanamide 

Relevant articles and documents

Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine

Various 5-phenoxy derivatives of primaquine have been prepared that are somewhat more effective and considerably less toxic that the parent compound in blood and tissue schizonticidal screens. Addition of a methyl group to the pyridine ring of the 5-phenoxyprimaquines has produced a number of antimalarials with potent activity against both blood and tissue schizonts.

Preparation of aromatic fluorides: Facile photo-induced fluorinative decomposition of arenediazonium salts and their related compounds using pyridine-nHF

By employing pyridine-nHF solution, the photo-induced fluorinative decomposition of arenediazonium salts (ArN2BF4) (fluoro-dediazoniation) and the related compounds, such as quinonediazides and triazenes, has been successfully carried out to produce the corresponding aromatic fluorides (ArF) in good yields. The rate in the fluoro-dediazoniation of para-substituted ArN2BF4 in pyridine-nHF solution did not obey the classical Hammett equation but conformed well to Taft's treatment [dual substituent parameter relationships (DSP)]. In the thermal fluoro-dediazoniation of ArN2BF4 the rate of reaction was significantly influenced by the substituents in the substrates. On the contrary, only a slight effect by the substituents was observed on the rate of the photo-induced fluoro-dediazoniation of ArN2BF4.