61721-07-1

Usage

Chemical Properties

Colorless to pale yellow liquid

Uses

4-Fluoro-3-trifluoromethylphenol

InChI:InChI=1/C7H4F4O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H

Upstream product

• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 

Downstream Products

• 361377-26-6 4-chloro-5-fluoro-6-[4-fluoro-3-(trifluoromethyl)phenoxy]pyrimidine 
• 254895-18-6 6-[(α,α,α,4-Tetrafluoro-m-tolyl)oxy]-4-pyrimidinyl α,α,α,-trifluoro-m-tolyl ketone 
• 289-95-2 PYRIMIDINE 
• 129578-83-2 potassium 4-fluoro-3-(trifluoromethyl)phenoxide 
• 1354819-15-0 4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenol 
• 1354819-07-0 tert-butyl ({5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]phenyl}sulfonyl)1,3-thiazol-4-ylcarbamate 
• 1354818-80-6 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 
• 1354819-08-1 5-chloro-2-fluoro-4-[4-fluoro-2-pyridazin-4-yl-5-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide 4-methylbenzenesulfonate 
• 1354819-14-9 4-fluoro-2-iod-5-(trifluoromethyl)phenol 
• 1363132-76-6 2-{8-[4-fluoro-3-(trifluoromethyl)phenoxy]-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol 
• 1369254-87-4 2-(4-fluoro-3-(trifluoromethyl)phenoxy)-5-formylbenzonitrile 
• 1402004-40-3 2-chloro-4-fluoro-3-(trifluoromethyl)phenol 
• 1402911-34-5 trans-3-{[4-fluoro-3-(trifluoromethyl)phenyl]oxy}-N-(imidazo[1,2-a]pyridin-8-ylmethyl)cyclobutanamine, hydrochloride 

Relevant academic research and scientific papers

Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine

Various 5-phenoxy derivatives of primaquine have been prepared that are somewhat more effective and considerably less toxic that the parent compound in blood and tissue schizonticidal screens. Addition of a methyl group to the pyridine ring of the 5-phenoxyprimaquines has produced a number of antimalarials with potent activity against both blood and tissue schizonts.

Process for preparing 4-fluoro-3-trifluoromethylphenol

Disclosed is a process for preparing 4-fluoro-3-trifluoromethylphenol from 4-fluoro-3-trifluoromethylaniline, which comprises the steps of (1) using about 1 to 20 parts by weight of water based on 1 part by weight of 4-fluoro-3-trifluoromethylaniline in t

Preparation of aromatic fluorides: Facile photo-induced fluorinative decomposition of arenediazonium salts and their related compounds using pyridine-nHF

By employing pyridine-nHF solution, the photo-induced fluorinative decomposition of arenediazonium salts (ArN2BF4) (fluoro-dediazoniation) and the related compounds, such as quinonediazides and triazenes, has been successfully carried out to produce the corresponding aromatic fluorides (ArF) in good yields. The rate in the fluoro-dediazoniation of para-substituted ArN2BF4 in pyridine-nHF solution did not obey the classical Hammett equation but conformed well to Taft's treatment [dual substituent parameter relationships (DSP)]. In the thermal fluoro-dediazoniation of ArN2BF4 the rate of reaction was significantly influenced by the substituents in the substrates. On the contrary, only a slight effect by the substituents was observed on the rate of the photo-induced fluoro-dediazoniation of ArN2BF4.

Facile Preparation of Aromatic Fluorides by the Fluoro-Dediazoniation of Aromatic Diazonium Tetrafluoroborates Using HF-Pyridine Solution

The fluoro-dediazoniation of ArN2BF4 using HF-pyridine solution has been successfully carried out either thermaly or photochemically to afford the corresponding ArF in good yields.Particularly, the photochemically induced reaction in HF-pyridine was a useful tool for the preparation of ArF having polar substituents such as halogens, OH, OMe, CF3, etc.