methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

Base Information

Chemical Name:methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate
CAS No.:1419603-28-3
Molecular Formula:C₂₁H₂₈FN₃O₄Si
Molecular Weight:433.555
Hs Code.:

Synonyms:methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

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Chemical Property of methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

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Technology Process of methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

There total 7 articles about methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1419603-26-1
methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

: 1419603-28-3
methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 2h; under 2585.81 Torr; Inert atmosphere;

Reference yield:

: 1419603-23-8
N-(4-fluorophenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-((2-(trimethylsilyl)ethoxy)-methyl)pyrimidine-2-carboxamide

: 1419603-28-3
methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In ethyl acetate; toluene;

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1419603-28-3
methyl 2-(2-((4-fluorophenyl)((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / benzene / 2 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

3.2: 2 h / -5 - 20 °C

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 2585.81 Torr / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium hydride; sodium carbonate; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; benzene;