(R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate

Base Information

• Chemical Name: (R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate
• CAS No.: 1169776-80-0
• Molecular Formula: C₂₄H₂₀Cl₂N₂O₅
• Molecular Weight: 487.339
• Mol file: 1169776-80-0.mol

Synonyms:(R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate

Chemical Property of (R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate

There total 1 articles about (R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

N-benzyloxycarbonyl-D-alanine (26607-51-2) + 4-chloro-N-(4-chloro-phenyl)-2-hydroxy-benzamide (106628-82-4) → (R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate (1169776-80-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -10 - 4 ℃; for 24h;

DOI:10.1016/j.bmc.2009.04.008

Reference yield:

(R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate (1169776-80-0) → BrH*C16H14Cl2N2O3 (1227476-87-0)

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.3390/molecules16032414

Reference yield:

(R)-5-chloro-2-(4-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)propanoate (1169776-80-0) → C16H14Cl2N2O3 (1227477-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / acetic acid

2: triethylamine / chloroform

With hydrogen bromide; triethylamine; In chloroform; acetic acid;

DOI:10.3390/molecules16032414

upstream raw materials:

N-benzyloxycarbonyl-D-alanine

4-chloro-N-(4-chloro-phenyl)-2-hydroxy-benzamide

Downstream raw materials:

BrH*C₁₆H₁₄Cl₂N₂O₃

C₁₆H₁₄Cl₂N₂O₃