2454-72-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-5-methoxy-2-nitrobenzaldehyde is used as a chemical intermediate for the synthesis of pyrrolobenzodiazepines, which are a class of compounds with potential applications in the development of anti-cancer drugs. These compounds have shown to inhibit DNA synthesis and have been studied for their potential use in treating various types of cancer.
Used in Biotechnology Industry:
In the biotechnology field, 4-hydroxy-5-methoxy-2-nitrobenzaldehyde is utilized in the preparation of antibody conjugates. These conjugates are essential for various diagnostic and therapeutic applications, such as targeted drug delivery and imaging techniques. The compound's functional groups allow for the attachment of antibodies to other molecules, enhancing their specificity and effectiveness in biological systems.

InChI:InChI=1/C8H7NO5/c1-14-8-2-5(4-10)6(9(12)13)3-7(8)11/h2-4,11H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 67-56-1 methanol 
• 881-68-5 vanillin acetate 
• 7697-37-2 nitric acid 
• 121-33-5 vanillin 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 876497-48-2 5-methoxy-2-nitro-4-(2-nitro-benzyloxy)-benzaldehyde 
• 81307-10-0 5-methoxy-2-nitro-4-(4-nitro-benzyloxy)-benzaldehyde 
• 81307-09-7 3-methoxy-4-[(4-nitrophenyl)methoxy]benzaldehyde 

Downstream Products

• 112919-67-2 4-acetoxy-5-methoxy-2,β-dinitrostyrene 
• 20357-25-9 6-nitroveratraldehyde 
• 84333-01-7 4-acetoxy-5-methoxy-2-nitro-benzaldehyde 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 600731-40-6 4-(6'-hydroxyhexyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 73635-75-3 4,5-dihydroxy-2-nitrobenzaldehyde 

Relevant academic research and scientific papers

Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group a

POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are useful as medicaments, in particular for use as a drug in an antibody-drug conjugate and in the treatment of a proliferative disease, a bacterial infection, a malarial infection and inflammation.

G-A CROSSLINKING CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or salts, solvates, isomers or tautomers thereof, wherein; A is a group selected from: R1 is selected from H and halogen; either R2 is selected from -CH2-halogen, C1

Preparation method of disulfide bond-containing dual-response functional molecule and hydrogel microsphere and application thereof

The invention discloses a disulfide bond-containing dual-response functional molecule, and the structural general formula of the disulfide bond-containing dual-response functional molecule is shown inthe specification. The invention also provides the dual

Photoactivatable trimethoprim-based probes for spatiotemporal control of biological processes

Optogenetic tools allow regulation of cellular processes with light, which can be delivered with spatiotemporal resolution. By combining the chemical versatility of photoremovable protecting groups with the biological specificity of self-labeling tags, we

Photoresponsive multifunctional chemical crosslinking agent and preparation method and application thereof

The invention discloses a photoresponsive multifunctional chemical crosslinking agent. The structure of the crosslinking agent is shown in a formula I, wherein the definition of each substituent groupin the formula I is shown in the description. The prepa

CYTOTOXIC AGENTS

The invention relates to a compound of formula (I) or formula (II) or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; which are useful as medicaments, in particular as anti-proliferative agents and for use as a d

EASILY DECOMPOSABLE LIGNIN GENERATOR

PROBLEM TO BE SOLVED: To provide an easily decomposable lignin generator containing a compound that can be introduced to a structure of lignin and can make lignin easily decomposable. SOLUTION: The easily decomposable lignin generator contains a compound represented by general formula (1), where R1 to R3 are identical or different and each represent a hydrogen atom, alkoxy group or alkyl group, R4 represents an organic group, and n represents an integer from 0 to 3. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

Nitration Using Fuming HNO3 in Sulfolane: Synthesis of 6-Nitrovanillin in Flow Mode

We report herein an improved synthesis of 6-nitrovanillin, an important building block used in pharmaceuticals and agrochemicals. The key step in this sequence is the nitration of O-Bn vanillin, which was carried out using fuming HNO3. Sulfolan

Scale-up Synthesis of Tesirine

This work describes the enabling synthesis of tesirine, a pyrrolobenzodiazepine antibody-drug conjugate drug-linker. Over the course of four synthetic campaigns, the discovery route was developed and scaled up to provide a robust manufacturing process. Early intermediates were produced on a kilogram scale and at high purity, without chromatography. Midstage reactions were optimized to minimize impurity formation. Late stage material was produced and purified using a small number of key high-pressure chromatography steps, ultimately resulting in a 169 g batch after 34 steps. At the time of writing, tesirine is the drug-linker component of eight antibody-drug conjugates in multiple clinical trials, four of them pivotal.