2454-72-0

Basic information

• Product Name: 4-hydroxy-5-methoxy-2-nitrobenzaldehyde
• Synonyms: Benzaldehyde,4-hydroxy-5-Methoxy-2-nitro-
• CAS NO: 2454-72-0
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• Mol File: 2454-72-0.mol
• Article Data: 28

Chemical Properties

• Melting Point: 207 °C
• Boiling Point: 399.3°Cat760mmHg
• Flash Point: 195.3°C
• Appearance: /
• Density: 1.456g/cm³
• Vapor Pressure: 5.99E-07mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.20±0.24(Predicted)
• CAS DataBase Reference: 4-hydroxy-5-methoxy-2-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-5-methoxy-2-nitrobenzaldehyde(2454-72-0)
• EPA Substance Registry System: 4-hydroxy-5-methoxy-2-nitrobenzaldehyde(2454-72-0)

Safety Data

• Hazardous Substances Data: 2454-72-0(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-5-methoxy-2-nitrobenzaldehyde is used in preparation of pyrrolobenzodiazepines and antibody conjugates.

InChI:InChI=1/C8H7NO5/c1-14-8-2-5(4-10)6(9(12)13)3-7(8)11/h2-4,11H,1H3

Upstream product

• 67-56-1 methanol 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 121-33-5 vanillin 
• 881-68-5 vanillin acetate 
• 7697-37-2 nitric acid 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 124-41-4 sodium methylate 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 876497-48-2 5-methoxy-2-nitro-4-(2-nitro-benzyloxy)-benzaldehyde 
• 81307-10-0 5-methoxy-2-nitro-4-(4-nitro-benzyloxy)-benzaldehyde 
• 81307-09-7 3-methoxy-4-[(4-nitrophenyl)methoxy]benzaldehyde 

Downstream Products

• 84333-01-7 4-acetoxy-5-methoxy-2-nitro-benzaldehyde 
• 40705-22-4 4-benzyloxy-6-bromo-3-methoxybenzaldehyde 
• 82583-95-7 2-amino-4-(benzyloxy)-5-methoxybenzaldehyde 
• 82583-97-9 4-benzyloxy-6-iodo-3-methoxybenzaldehyde 
• 176375-42-1 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester 
• 22281-11-4 4-(allyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 1430738-02-5 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzaldehyde 
• 1430738-49-0 (11S,11aS)-4-((S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanamido)benzyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-hydroxy-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate 

Relevant articles and documents

Cleavage of the methylenedioxy group with sodium methoxide in dimethyl sulfoxide

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POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are useful as medicaments, in particular for use as a drug in an antibody-drug conjugate and in the treatment of a proliferative disease, a bacterial infection, a malarial infection and inflammation.

G-A CROSSLINKING CYTOTOXIC AGENTS

The invention relates to a compound of formula (I): or salts, solvates, isomers or tautomers thereof, wherein; A is a group selected from: R1 is selected from H and halogen; either R2 is selected from -CH2-halogen, C1